Hypothyroidism: Symptoms, Causes, Diagnosis and Treatment of Underactive Thyroid

Hormone conditions can sometimes be difficult to recognise, often being attributed to other causes like getting older, poor diet. Symptoms like tiredness, weight gain, feeling cold, and dry skin could be signs of an underactive thyroid (Hypothyroidism). In this article we examine the symptoms, causes, diagnosis and treatment of hypothyroidism.

Hypothyroidism: Symptoms, Causes, Diagnosis and Treatment of Underactive Thyroid

What does your thyroid do?

The thyroid is a small gland in the front of your neck that produces thyroid hormone. The thyroid hormones control the way your body uses energy (your metabolic rate) – meaning it affects nearly organ in your body. Thyroid hormone is made up of two primary hormones thyroxine (T4) and triiodothyronine (T3) which impact your metabolism.

What is hypothyroidism?

Hypothyroidism is a condition where the thyroid gland does not produce enough thyroid hormone to meet your body’s needs. It’s otherwise known as underactive thyroid. With less thyroid hormone your bodies metabolism is slowed, leading to the development of a range of symptoms.

Hypothyroidism symptoms

The symptoms of hypothyroidism can be subtle and easy to miss in the beginning, developing over months or years. Some people may only notice such as tiredness or weight gain – often excused as normal or mistaken for other conditions.

 

Common symptoms of hypothyroidism may include:

  • Tiredness or low energy,
  • Feeling sluggish or brain fog,
  • Uneplained weight gain (no change in diet or lifestyle),
  • Muscle aches, cramps, stiffness or weakness,
  • Feeling cold most of the time,
  • Constipation,
  • Dry skin and/or hair,
  • Low mood or depression,
  • Irregular menstrual periods.

What causes hypothyroidism?

Hypothyroidism can have several causes, the most common of which is Hashimoto’s disease.

Hashimoto’s Disease

Otherwise known as chronic lymphocytic thyroiditis, this is an autoimmune disease where the immune system attacks the thyroid gland. Why your body does this is not known, but it causes inflammation and damage to your thyroid. Over time this can lead to hypothyroidism.

Other causes of hypothyroidism

  • Thyroid surgery in some cases (e.g., thyroid cancer), is required to remove part or all of the thyroid. Reducing or stopping the production thyroid hormone.
  • Radiation therapy, used to treat cancers of the thyroid, head, chest or neck can affect the thyroid gland.
  • Medicines can lead to hypothyroidism. Certain medicines like lithium and amiodarone can cause hypothyroidism to occur in some people.*
  • Medical conditions can be related to hypothyroidism, such as iodine deficiency, pituitary gland problems or thyroiditis
  • Thyroiditis is when the thyroid gland becomes inflamed. This can trigger the thyroid to release all of its stored thyroid hormone, after which it can become underactive.

*If you’re taking medicine and worried about hypothyroidism never stop taking as prescribed, ask your pharmacist or heathcare provider about its effect on the thyroid gland.

Who is more likely to develop hypothyroidism?

Anyone can develop hypothyroidism, but it is more common in women, along with people older than 60.

Other risk factors for hypothyroidism include:

  • Family history of thyroid disease,
  • Have had thyroid issues before (e.g., goitre),
  • Previous radioactive iodine treatment,
  • Have received radiation treatment to neck or chest,
  • Were pregnant in the last 6 months,
  • Have an autoimmune disease (e.g., type 1 diabetes or coeliac disease).

How is hypothyroidism diagnosed?

If you are worried about hypothyroidism you should see your healthcare provider. A doctor will perform a physical examination of your neck for thyroid enlargement (swelling). They will also ask you about your symptoms, medical history, family history, and medicines history.

 

Because the symptoms of hypothyroidism can often very common among other unrelated health conditions diagnosis usually involves blood tests for the level of thyroid stimulating hormone (TSH) in your blood, as well as the levels of each thyroid hormone (T3 and T4). They may also undertake imaging tests such as ultrasound, CT scan or thyroid uptake scan.

What is subclinical hypothyroidism?

Subclinical hypothyroidism also known as mild thyroid failure, is when your TSH levels are slightly raised, but your other thyroid hormone levels are still within normal range, meaning that there are often no symptoms.

 

For some people subclinical hypothyroidism will need to be treated, this can include people who:

  • Have symptoms of hypothyroidism.
  • Are pregnant or planning a pregnancy.
  • Have positive thyroid antibodies.
  • Have high TSH levels.

 

Your doctor may recommend repeat blood tests every 2-12 months as some people can go on to develop hypothyroidism.

Hypothyroidism treatment options?

Hypothyroidism is usually treated by replacing hormones that your thyroid is not making enough of, most often using the medicine levothyroxine, a synthetic form of the T4 hormone.

 

Levothyroxine is usually taken once a day, in the morning, on an empty stomach. Levothyroxine can restore your hormone levels and provide relief from your symptoms.

 

After starting levothyroxine your healthcare provider will run routine thyroid blood tests until your TSH levels even out. They may adjust the dosage during this period too. Once your levels are stable, the frequency of these tests will reduce depending on your situation.

 

Treatment with levothyroxine is often continued for life.

Taking multiple medicines? Our Monthly Medicines Service is free

Our service is designed to make managing multiple medicines easy. Our Monthly Medicines Service is free to eligible patients taking three or more regular medicines.